100&Change: 2021

Eradicating Trachoma, Once and for All

UCSF Proctor Foundation for Research in Ophthalmology

Trachoma was once the world’s leading cause of blindness, but with our three-fold approach, it will become the second human disease to be completely eradicated.

Submitted: August 2019
DOWNLOAD: Project Factsheet
Two-page overview of proposal
Competition Participation
100&Change: 2021
Current Work Location(s):
  • United States
  • Wadi Fira Region, Chad
  • Bamingui-Bangoran, Central African Republic
  • Maradi, Niger
  • Eastern Equatoria, South Sudan
  • Amhara Region, Ethiopia
Priority Population(s):
  • Children
  • Economically disadvantaged people
  • People with diseases and illnesses
Sustainable Development Goals (SDGs):
  • 1. No poverty
  • 3. Good health and well-being
  • 10. Reduced inequalities

Executive Summary

Trachoma is a bacterial disease of the eye leading to irreversible blindness and affecting nearly 2 million people worldwide. A decade of intervention has resulted in trachoma control in the majority of previously endemic regions, but progress has stalled in some difficult-to-control regions in sub-Saharan Africa. Mathematical models and clinical trials show that existing strategies will not work in these “hotspots.” Unless infection is rapidly eliminated in remaining areas, antimicrobial resistance could derail progress. Eradication of trachoma—the permanent reduction of cases to zero—is a sustainable solution that has now become achievable. We propose to use novel methods and technology to eliminate infection from these hard-to-treat regions. Through intensified and more frequent treatment, we will eliminate infection among “super-spreaders” to prevent further transmission. Finally, we will build new global labs for monitoring and rapid case detection. Through this new approach, we will eradicate trachoma forever.

Organization Details
Lead Organization

UCSF Proctor Foundation for Research in Ophthalmology

website: https://www.ucsf.edu/
Organization Headquarters
San Francisco County, California, United States
Organization ID
Annual Operating Budget
> $1 Billion
Number of Full-time Employees
> 1,000

Charity, fund, non-governmental organization, religious institution, school, or other entity